| 1. Round | 23/07/2022 | Sporting San Miguelito | - | Alianza | 0:1 | ||||
| 2. Round | 31/07/2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 5. Round | 14/08/2022 | Potros del Este | - | Sporting San Miguelito | 1:3 | ||||
| 6. Round | 21/08/2022 | Sporting San Miguelito | - | UD Universitario | 2:2 | ||||
| 7. Round | 28/08/2022 | Herrera FC | - | Sporting San Miguelito | 0:0 |  |
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| 8. Round | 03/09/2022 | Sporting San Miguelito | - | Veraguas United | 3:2 | ||||
| 9. Round | 12/09/2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 | ||||
| 10. Round | 18/09/2022 | Atlético Chiriquí | - | Sporting San Miguelito | 0:0 | ||||
| 11. Round | 24/09/2022 | Independiente de La Chorrera | - | Sporting San Miguelito | 0:2 | ||||
| 12. Round | 28/09/2022 | Alianza | - | Sporting San Miguelito | 1:0 | ||||
| 13. Round | 02/10/2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | |
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| 14. Round | 08/10/2022 | Árabe Unido | - | Sporting San Miguelito | 1:1 | ||||
| 15. Round | 17/10/2022 | Tauro FC | - | Sporting San Miguelito | 2:0 | ||||
| 16. Round | 22/10/2022 | Sporting San Miguelito | - | Potros del Este | 3:2 |
Panama