| 1. Round | 15/08/2021 | FC Utrecht | - | Sparta Rotterdam | 4:0 | ||||
| 2. Round | 21/08/2021 | Sparta Rotterdam | - | Heracles Almelo | 1:1 | ||||
| 3. Round | 28/08/2021 | Go Ahead Eagles | - | Sparta Rotterdam | 2:0 |  |
|||
| 5. Round | 17/09/2021 | Sparta Rotterdam | - | NEC Nijmegen | 1:1 | ||||
| 6. Round | 22/09/2021 | PEC Zwolle | - | Sparta Rotterdam | 1:1 | ||||
| 7. Round | 26/09/2021 | Sparta Rotterdam | - | SC Cambuur | 0:4 | ||||
| 8. Round | 03/10/2021 | PSV Eindhoven | - | Sparta Rotterdam | 2:1 | ||||
| 9. Round | 17/10/2021 | Sparta Rotterdam | - | FC Groningen | 1:1 | ||||
| 10. Round | 23/10/2021 | RKC Waalwijk | - | Sparta Rotterdam | 1:0 | ||||
| 14. Round | 28/11/2021 | Sparta Rotterdam | - | AFC Ajax | 0:1 | ||||
| 18. Round | 23/12/2021 | Sparta Rotterdam | - | RKC Waalwijk | 1:1 | ||||
| 21. Round | 06/02/2022 | Feyenoord | - | Sparta Rotterdam | 4:0 | ||||
| 22. Round | 13/02/2022 | Sparta Rotterdam | - | Willem II | 1:0 | ||||
| 30. Round | 22/04/2022 | FC Twente | - | Sparta Rotterdam | 2:0 | ||||
| 32. Round | 07/05/2022 | FC Groningen | - | Sparta Rotterdam | 1:2 | |
|||
| 34. Round | 15/05/2022 | Heracles Almelo | - | Sparta Rotterdam | 1:3 |
Belgium