| 1. Round | 14/08/2021 | Hamburger SV [Youth] | - | RB Leipzig [Youth] | 0:3 |  |
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| 2. Round | 21/08/2021 | RB Leipzig [Youth] | - | FC St. Pauli [Youth] | 2:2 | ||||
| 3. Round | 11/09/2021 | FC Carl Zeiss Jena [Youth] | - | RB Leipzig [Youth] | 0:1 | |
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| 5. Round | 25/09/2021 | Holstein Kiel [Youth] | - | RB Leipzig [Youth] | 2:2 | ||||
| 8. Round | 23/10/2021 | Eimsbütteler TV [Youth] | - | RB Leipzig [Youth] | 3:6 |  |
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| 9. Round | 29/10/2021 | RB Leipzig [Youth] | - | Dynamo Dresden [Youth] | 0:3 | |
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| 10. Round | 20/11/2021 | FC Viktoria 1889 Berlin [Youth] | - | RB Leipzig [Youth] | 0:0 | ||||
| 11. Round | 12/02/2022 | RB Leipzig [Youth] | - | Hallescher FC [Youth] | 7:0 | ||||
| 14. Round | 26/02/2022 | Hertha BSC [Youth] | - | RB Leipzig [Youth] | 1:4 | ||||
| 15. Round | 05/03/2022 | RB Leipzig [Youth] | - | 1. FC Magdeburg [Youth] | 1:3 | ||||
| 12. Round | 12/03/2022 | VfL Wolfsburg [Youth] | - | RB Leipzig [Youth] | 0:1 | ||||
| 16. Round | 02/04/2022 | 1. FC Union Berlin [Youth] | - | RB Leipzig [Youth] | 1:2 | ||||
| 17. Round | 09/04/2022 | RB Leipzig [Youth] | - | Hannover 96 [Youth] | 2:0 | |
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| 19. Round | 30/04/2022 | RB Leipzig [Youth] | - | Energie Cottbus [Youth] | 1:1 |
Germany