| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 | ||||
| 2. Round | 15/07/2022 | Deportes Tolima | - | Deportivo Cali | 2:0 |  |
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| 3. Round | 19/07/2022 | Unión Magdalena | - | Deportes Tolima | 2:1 | ||||
| 4. Round | 24/07/2022 | Deportes Tolima | - | Atlético Nacional | 2:2 | |
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| 5. Round | 02/08/2022 | Atlético Bucaramanga | - | Deportes Tolima | 2:1 | ||||
| 6. Round | 06/08/2022 | Deportes Tolima | - | Jaguares de Córdoba | 2:2 | ||||
| 7. Round | 13/08/2022 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 |  |
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| 11. Round | 10/09/2022 | Patriotas FC | - | Deportes Tolima | 1:1 |
Colombia