| 2. Round | 07/08/2022 | Olimpia | - | Victoria | 2:0 |  |
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| 3. Round | 11/08/2022 | Marathón | - | Olimpia | 1:2 | ||||
| 4. Round | 14/08/2022 | Olancho FC | - | Olimpia | 0:1 | ||||
| 5. Round | 21/08/2022 | Olimpia | - | Real España | 1:1 | ||||
| 6. Round | 28/08/2022 | Olimpia | - | Lobos UPNFM | 2:0 | |
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| 7. Round | 02/09/2022 | Motagua | - | Olimpia | 1:0 | ||||
| 8. Round | 04/09/2022 | Olimpia | - | Honduras Progreso | 1:1 | ||||
| 9. Round | 11/09/2022 | Real Sociedad | - | Olimpia | 2:2 | |
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| 10. Round | 19/09/2022 | Olimpia | - | Vida | 2:0 |  |
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| 11. Round | 02/10/2022 | Victoria | - | Olimpia | 0:2 | |
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| 12. Round | 09/10/2022 | Olimpia | - | Marathón | 1:0 | ||||
| 13. Round | 16/10/2022 | Olimpia | - | Olancho FC | 0:1 | ||||
| 14. Round | 20/10/2022 | Real España | - | Olimpia | 0:0 | ||||
| 15. Round | 23/10/2022 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 16. Round | 07/11/2022 | Olimpia | - | Motagua | 4:0 | |
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| 17. Round | 13/11/2022 | Honduras Progreso | - | Olimpia | 1:2 | |
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| 18. Round | 19/11/2022 | Olimpia | - | Real Sociedad | 2:0 |
Honduras