| 5. Round | 03/10/2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 7. Round | 25/10/2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | ||||
| 9. Round | 07/11/2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 11. Round | 29/11/2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 12. Round | 04/12/2021 | Anorthosis Famagusta | - | PAEEK | 2:3 |  |
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| 1. Round | 22/12/2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | ||||
| 17. Round | 16/01/2022 | Anorthosis Famagusta | - | AEL Limassol | 2:1 | ||||
| 18. Round | 24/01/2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Round | 29/01/2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | |
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| 20. Round | 06/02/2022 | Paphos FC | - | Anorthosis Famagusta | 1:1 | ||||
| 15. Round | 10/02/2022 | Anorthosis Famagusta | - | Aris Limassol | 3:1 | ||||
| 16. Round | 17/02/2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Round | 26/02/2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
Cyprus