| 2. Round | 24/09/2021 | SS Virtus | - | SS Cosmos | 2:0 | ||||
| 10. Round | 28/11/2021 | SS San Giovanni | - | SS Cosmos | 5:1 | ||||
| 11. Round | 04/12/2021 | SS Cosmos | - | FC Domagnano | 0:0 | ||||
| 13. Round | 18/12/2021 | SS Cosmos | - | AC Juvenes/Dogana | 1:1 | ||||
| 21. Round | 16/02/2022 | SS Murata | - | SS Cosmos | 3:0 | ||||
| 26. Round | 13/03/2022 | FC Domagnano | - | SS Cosmos | 1:0 | ||||
| 15. Round | 16/03/2022 | SS Cosmos | - | SS Pennarossa | 0:3 | ||||
| 27. Round | 19/03/2022 | SS Cosmos | - | SP Cailungo | 1:3 | ||||
| 17. Round | 06/04/2022 | SS Cosmos | - | SS Virtus | 0:2 | ||||
| 28. Round | 09/04/2022 | AC Juvenes/Dogana | - | SS Cosmos | 3:1 | ||||
| 29. Round | 14/04/2022 | SS Cosmos | - | SS Folgore/Falciano | 2:5 |
San Marino