| 1. Round | 13/08/2021 | Hamrun Spartans | - | Valletta FC | 1:2 | ||||
| 2. Round | 21/08/2021 | Valletta FC | - | Balzan FC | 1:0 | ||||
| 3. Round | 11/09/2021 | Floriana FC | - | Valletta FC | 3:0 | ||||
| 4. Round | 18/09/2021 | Valletta FC | - | Gżira United | 0:2 | ||||
| 5. Round | 25/09/2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 9. Round | 20/11/2021 | Sliema Wanderers | - | Valletta FC | 0:3 dec. | ||||
| 13. Round | 19/12/2021 | Balzan FC | - | Valletta FC | 2:1 | ||||
| 14. Round | 17/01/2022 | Valletta FC | - | Floriana FC | 0:2 | ||||
| 15. Round | 23/01/2022 | Gżira United | - | Valletta FC | 1:1 | ||||
| 16. Round | 30/01/2022 | Valletta FC | - | Gudja United | 1:3 |  |
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| 19. Round | 20/02/2022 | St. Luċija FC | - | Valletta FC | 2:1 | ||||
| 20. Round | 26/02/2022 | Valletta FC | - | Sliema Wanderers | 1:0 |
Malta