6. Round | 09/08/2022 | Barranquilla FC | - | Leones FC | 3:1 | ||||
7. Round | 16/08/2022 | Leones FC | - | Cúcuta Deportivo | 1:1 | ||||
8. Round | 22/08/2022 | Boca Juniors de Cali | - | Leones FC | 1:1 | ||||
9. Round | 27/08/2022 | Leones FC | - | Valledupar FC | 1:0 | ||||
10. Round | 02/09/2022 | Leones FC | - | Fortaleza FC | 1:1 | ||||
11. Round | 07/09/2022 | Atlético FC | - | Leones FC | 4:0 | ||||
12. Round | 13/09/2022 | Leones FC | - | Atlético Huila | 2:2 | ||||
13. Round | 18/09/2022 | Orsomarso SC | - | Leones FC | 1:4 | ||||
14. Round | 24/09/2022 | Valledupar FC | - | Leones FC | 0:3 dec. | ||||
16. Round | 08/10/2022 | Deportes Quindío | - | Leones FC | 3:2 |