2. Round | 12/08/2021 | Olimpia | - | Real España | 1:1 | ||||
3. Round | 15/08/2021 | Platense | - | Real España | 0:2 | ||||
9. Round | 16/09/2021 | Honduras Progreso | - | Real España | 1:1 | ||||
13. Round | 10/10/2021 | Victoria | - | Real España | 0:2 | ||||
14. Round | 17/10/2021 | Real España | - | Platense | 2:1 | ||||
1. Round | 21/10/2021 | Real España | - | Victoria | 1:1 | ||||
16. Round | 28/10/2021 | Real España | - | Honduras Progreso | 4:1 |