1. Round | 20/01/2022 | Victoria | - | Real España | 4:1 | ||||
2. Round | 23/01/2022 | Platense | - | Real España | 2:1 | ||||
5. Round | 13/02/2022 | Real España | - | Real Sociedad | 4:1 | ||||
7. Round | 27/02/2022 | Real España | - | Honduras Progreso | 3:0 | ||||
15. Round | 14/04/2022 | Lobos UPNFM | - | Real España | 0:2 |