1. Round | 01/08/2021 | Managua FC | - | Juventus Managua | 0:1 | ||||
2. Round | 09/08/2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
3. Round | 16/08/2021 | Managua FC | - | Real Estelí FC | 3:0 | ||||
11. Round | 10/10/2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | ||||
12. Round | 17/10/2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
13. Round | 21/10/2021 | Managua FC | - | H&H Export Sébaco | 1:2 | ||||
14. Round | 25/10/2021 | Diriangén FC | - | Managua FC | 0:3 | ||||
15. Round | 31/10/2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
18. Round | 22/11/2021 | Managua FC | - | CD Walter Ferretti | 3:1 |