| 1. Round | 21/01/2022 | H&H Export Sébaco | - | Real Estelí FC | 4:4 | ||||
| 2. Round | 07/02/2022 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 3. Round | 11/02/2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 0:0 |  |
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| 4. Round | 14/02/2022 | Managua FC | - | H&H Export Sébaco | 3:2 | ||||
| 5. Round | 19/02/2022 | Juventus Managua | - | H&H Export Sébaco | 5:1 | ||||
| 6. Round | 27/02/2022 | CD Walter Ferretti | - | H&H Export Sébaco | 5:0 | |
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| 8. Round | 05/03/2022 | H&H Export Sébaco | - | Diriangén FC | 4:0 | ||||
| 9. Round | 09/03/2022 | H&H Export Sébaco | - | Real Madriz | 1:1 | ||||
| 10. Round | 14/03/2022 | Real Estelí FC | - | H&H Export Sébaco | 3:3 | ||||
| 11. Round | 19/03/2022 | UNAN Managua | - | H&H Export Sébaco | 3:3 |  |
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| 12. Round | 03/04/2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 4:1 | |
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| 14. Round | 09/04/2022 | H&H Export Sébaco | - | Juventus Managua | 2:0 | |
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| 15. Round | 14/04/2022 | ART Municipal Jalapa | - | H&H Export Sébaco | 1:0 | ||||
| 16. Round | 24/04/2022 | H&H Export Sébaco | - | CD Walter Ferretti | 2:0 | ||||
| 17. Round | 29/04/2022 | Diriangén FC | - | H&H Export Sébaco | 8:0 | ||||
| 18. Round | 01/05/2022 | Real Madriz | - | H&H Export Sébaco | 0:0 |
Argentina