| 2. Round | 13/02/2022 | UD Universitario | - | Atlético Chiriquí | 0:1 | ||||
| 3. Round | 20/02/2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | ||||
| 4. Round | 27/02/2022 | Herrera FC | - | Atlético Chiriquí | 1:2 | ||||
| 5. Round | 06/03/2022 | Veraguas United | - | Atlético Chiriquí | 1:3 | ||||
| 6. Round | 10/03/2022 | Plaza Amador | - | Atlético Chiriquí | 2:1 |  |
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| 7. Round | 12/03/2022 | Atlético Chiriquí | - | Tauro FC | 1:0 | ||||
| 8. Round | 19/03/2022 | Potros del Este | - | Atlético Chiriquí | 2:2 |  |
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| 9. Round | 27/03/2022 | Atlético Chiriquí | - | Árabe Unido | 1:0 | ||||
| 10. Round | 04/04/2022 | Sporting San Miguelito | - | Atlético Chiriquí | 4:1 | |
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| 14. Round | 27/04/2022 | San Francisco FC | - | Atlético Chiriquí | 2:2 | ||||
| 15. Round | 02/05/2022 | Atlético Chiriquí | - | Herrera FC | 0:0 | |
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| 16. Round | 07/05/2022 | Atlético Chiriquí | - | Veraguas United | 2:1 | |
Panama