| 15. Round | 05/11/2021 | Chindia Târgoviște | - | Gaz Metan Mediaş | 0:1 | ||||
| 16. Round | 22/11/2021 | CS Mioveni | - | Gaz Metan Mediaş | 1:0 |  |
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| 17. Round | 29/11/2021 | Gaz Metan Mediaş | - | Farul Constanța | 1:1 | ||||
| 18. Round | 06/12/2021 | Argeș Pitești | - | Gaz Metan Mediaş | 1:2 | ||||
| 19. Round | 11/12/2021 | Gaz Metan Mediaş | - | FCSB | 0:1 | ||||
| 20. Round | 15/12/2021 | FC Botoşani | - | Gaz Metan Mediaş | 2:1 | ||||
| 21. Round | 18/12/2021 | Gaz Metan Mediaş | - | CS Universitatea Craiova | 1:1 | ||||
| 22. Round | 23/01/2022 | UTA Arad | - | Gaz Metan Mediaş | 0:1 | ||||
| 23. Round | 29/01/2022 | FC Voluntari | - | Gaz Metan Mediaş | 3:1 | ||||
| 24. Round | 04/02/2022 | Gaz Metan Mediaş | - | Rapid Bucureşti | 1:1 | ||||
| 25. Round | 08/02/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 | ||||
| 26. Round | 12/02/2022 | Gaz Metan Mediaş | - | CFR Cluj | 1:2 | ||||
| 27. Round | 18/02/2022 | Dinamo Bucureşti | - | Gaz Metan Mediaş | 4:0 |
Romania