| 5. Round | 12/09/2015 | Roda JC Kerkrade | - | NEC Nijmegen | 0:0 | ||||
| 6. Round | 18/09/2015 | NEC Nijmegen | - | sc Heerenveen | 2:0 | ||||
| 7. Round | 26/09/2015 | PSV Eindhoven | - | NEC Nijmegen | 2:1 | ||||
| 8. Round | 03/10/2015 | NEC Nijmegen | - | ADO Den Haag | 4:1 | ||||
| 21. Round | 30/01/2016 | NEC Nijmegen | - | AZ Alkmaar | 0:3 | ||||
| 22. Round | 07/02/2016 | De Graafschap | - | NEC Nijmegen | 1:1 | ||||
| 23. Round | 14/02/2016 | NEC Nijmegen | - | PSV Eindhoven | 0:3 | ||||
| 24. Round | 20/02/2016 | sc Heerenveen | - | NEC Nijmegen | 1:1 | ||||
| 29. Round | 03/04/2016 | NEC Nijmegen | - | Vitesse | 2:1 | ||||
| 30. Round | 10/04/2016 | FC Utrecht | - | NEC Nijmegen | 3:1 | ||||
| 31. Round | 17/04/2016 | NEC Nijmegen | - | SC Cambuur | 2:1 |  |
|||
| 32. Round | 20/04/2016 | PEC Zwolle | - | NEC Nijmegen | 2:0 | ||||
| 33. Round | 01/05/2016 | NEC Nijmegen | - | Roda JC Kerkrade | 1:2 |
Romania