| 1. Round | 18/07/2021 | Spartak Subotica | - | Radnički Niš | 1:1 | ||||
| 2. Round | 23/07/2021 | FK Radnički 1923 | - | Spartak Subotica | 3:2 | ||||
| 3. Round | 31/07/2021 | Spartak Subotica | - | Crvena Zvezda | 1:3 | ||||
| 4. Round | 07/08/2021 | Mladost Lučani | - | Spartak Subotica | 1:2 | ||||
| 5. Round | 16/08/2021 | Spartak Subotica | - | Vojvodina | 2:2 |  |
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| 6. Round | 22/08/2021 | Spartak Subotica | - | FK Napredak | 3:2 | ||||
| 7. Round | 28/08/2021 | Radnik Surdulica | - | Spartak Subotica | 1:2 |  |
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| 12. Round | 02/10/2021 | Spartak Subotica | - | FK Voždovac | 0:4 | ||||
| 15. Round | 02/11/2021 | FK Kolubara | - | Spartak Subotica | 1:2 | ||||
| 16. Round | 07/11/2021 | Radnički Niš | - | Spartak Subotica | 0:0 | ||||
| 17. Round | 21/11/2021 | Spartak Subotica | - | FK Radnički 1923 | 1:1 | ||||
| 18. Round | 28/11/2021 | Crvena Zvezda | - | Spartak Subotica | 3:0 | ||||
| 19. Round | 05/12/2021 | Spartak Subotica | - | Mladost Lučani | 0:0 | ||||
| 21. Round | 18/12/2021 | FK Napredak | - | Spartak Subotica | 1:0 |
Serbia