| 11. Round | 25/09/2021 | Cobán Imperial | - | Iztapa | 2:1 | ||||
| 12. Round | 02/10/2021 | Cobán Imperial | - | Xelaju MC | 1:1 | ||||
| 13. Round | 10/10/2021 | Sololá FC | - | Cobán Imperial | 1:2 | ||||
| 8. Round | 13/10/2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 | ||||
| 14. Round | 17/10/2021 | Cobán Imperial | - | Nueva Concepción | 2:0 |  |
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| 15. Round | 23/10/2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 16. Round | 27/10/2021 | Cobán Imperial | - | Comunicaciones | 1:2 | ||||
| 17. Round | 31/10/2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Round | 07/11/2021 | Antigua GFC | - | Cobán Imperial | 2:1 | |
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| 19. Round | 13/11/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 |
Costa Rica