| 2. Round | 18/07/2022 | UNAN Managua | - | Diriangén FC | 1:2 |  |
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| 3. Round | 24/07/2022 | ART Municipal Jalapa | - | UNAN Managua | 3:3 | ||||
| 5. Round | 07/08/2022 | H&H Export Sébaco | - | UNAN Managua | 5:0 | ||||
| 6. Round | 12/08/2022 | UNAN Managua | - | Juventus Managua | 2:1 | ||||
| 8. Round | 21/08/2022 | Real Estelí FC | - | UNAN Managua | 1:0 | ||||
| 9. Round | 29/08/2022 | Managua FC | - | UNAN Managua | 2:1 | ||||
| 10. Round | 03/09/2022 | UNAN Managua | - | CD Walter Ferretti | 0:3 | ||||
| 11. Round | 12/09/2022 | Diriangén FC | - | UNAN Managua | 4:2 | ||||
| 13. Round | 23/10/2022 | Club Deportivo Ocotal | - | UNAN Managua | 2:3 | ||||
| 14. Round | 27/10/2022 | UNAN Managua | - | H&H Export Sébaco | 0:0 | ||||
| 15. Round | 31/10/2022 | Juventus Managua | - | UNAN Managua | 2:1 | ||||
| 16. Round | 23/11/2022 | Matagalpa FC | - | UNAN Managua | 3:3 | ||||
| 17. Round | 28/11/2022 | UNAN Managua | - | Real Estelí FC | 1:4 | ||||
| 18. Round | 01/12/2022 | UNAN Managua | - | Managua FC | 1:3 |
Nicaragua