| 2. Round | 17/07/2022 | Valledupar FC | - | Boyacá Chicó | 0:0 | ||||
| 5. Round | 04/08/2022 | Valledupar FC | - | Llaneros FC | 1:1 | ||||
| 6. Round | 08/08/2022 | Boca Juniors de Cali | - | Valledupar FC | 2:0 | ||||
| 7. Round | 14/08/2022 | Valledupar FC | - | Tigres FC | 1:1 | ||||
| 8. Round | 23/08/2022 | Valledupar FC | - | Bogotá FC | 3:3 |  |
|||
| 10. Round | 03/09/2022 | Valledupar FC | - | Real Cartagena | 1:1 | ||||
| 11. Round | 07/09/2022 | Real Santander | - | Valledupar FC | 1:0 | ||||
| 12. Round | 11/09/2022 | Valledupar FC | - | Atlético FC | 1:0 | |
|||
| 13. Round | 18/09/2022 | Cúcuta Deportivo | - | Valledupar FC | 2:1 |  |
|||
| 14. Round | 24/09/2022 | Valledupar FC | - | Leones FC | 0:3 dec. | |
|||
| 15. Round | 01/10/2022 | Valledupar FC | - | Barranquilla FC | 0:1 | |
|||
| 16. Round | 08/10/2022 | Fortaleza FC | - | Valledupar FC | 3:1 | |
Colombia