| 1. Round | 26/02/2022 | Inter Miami CF | - | Chicago Fire | 0:0 | ||||
| 2. Round | 06/03/2022 | Austin FC | - | Inter Miami CF | 5:1 | ||||
| 2. Round | 12/03/2022 | Inter Miami CF | - | Los Angeles FC | 0:2 |  |
|||
| 2. Round | 19/03/2022 | FC Cincinnati | - | Inter Miami CF | 3:1 | |
|||
| 3. Round | 03/04/2022 | Inter Miami CF | - | Houston Dynamo | 1:3 | ||||
| 3. Round | 17/04/2022 | Seattle Sounders | - | Inter Miami CF | 0:1 | |
|||
| 3. Round | 24/04/2022 | Inter Miami CF | - | Atlanta United FC | 2:1 | ||||
| 4. Round | 01/05/2022 | New England Revolution | - | Inter Miami CF | 2:0 |
England
Eritrea