| 1. Round | 25/10/2021 | Smouha Sporting Club | - | Ittihad El Iskandary | 4:4 | ||||
| 3. Round | 05/11/2021 | Smouha Sporting Club | - | El Sharkia Lel Dokhan | 3:0 | ||||
| 6. Round | 25/11/2021 | Al Ahly SC | - | Smouha Sporting Club | 4:1 | ||||
| 7. Round | 21/12/2021 | Smouha Sporting Club | - | Ismaily | 2:1 | ||||
| 5. Round | 25/12/2021 | Smouha Sporting Club | - | Tala'ea El Gaish SC | 1:0 | ||||
| 8. Round | 10/02/2022 | National Bank SC | - | Smouha Sporting Club | 1:2 | ||||
| 9. Round | 15/02/2022 | Smouha Sporting Club | - | Zamalek | 2:0 |  |
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| 11. Round | 27/02/2022 | Smouha Sporting Club | - | Ghazl Al Mehalla | 2:0 | ||||
| 12. Round | 08/03/2022 | Ceramica Cleopatra | - | Smouha Sporting Club | 1:1 | ||||
| 15. Round | 20/04/2022 | El Gouna | - | Smouha Sporting Club | 1:0 | ||||
| 17. Round | 29/04/2022 | Pharco FC | - | Smouha Sporting Club | 0:0 | ||||
| 14. Round | 06/05/2022 | Smouha Sporting Club | - | Pyramids FC | 0:2 | ||||
| 21. Round | 28/05/2022 | Smouha Sporting Club | - | ENPPI | 1:1 | ||||
| 27. Round | 27/07/2022 | Smouha Sporting Club | - | Al Mokawloon | 1:1 | ||||
| 32. Round | 23/08/2022 | Smouha Sporting Club | - | El Gouna | 2:2 |
Egypt