| 16. Round | 22/04/2021 | El Entag El Harby | - | Zamalek | 0:2 |  |
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| 21. Round | 10/05/2021 | Al Ahly SC | - | Zamalek | 1:1 | ||||
| 22. Round | 14/05/2021 | Zamalek | - | ENPPI | 3:1 | |
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| 23. Round | 20/05/2021 | Zamalek | - | Tala'ea El Gaish SC | 2:1 | ||||
| 24. Round | 24/05/2021 | Zamalek | - | Al Masry Club | 3:2 | ||||
| 26. Round | 17/06/2021 | Zamalek | - | Aswan SC | 3:0 | ||||
| 27. Round | 28/06/2021 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 28. Round | 07/08/2021 | Zamalek | - | Ghazl Al Mehalla | 3:0 | ||||
| 29. Round | 10/08/2021 | Ittihad El Iskandary | - | Zamalek | 1:2 |  |
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| 30. Round | 14/08/2021 | Ismaily | - | Zamalek | 0:2 | |
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| 32. Round | 20/08/2021 | Ceramica Cleopatra | - | Zamalek | 1:2 | ||||
| 33. Round | 24/08/2021 | Zamalek | - | El Entag El Harby | 2:0 |
Egypt