| 1. Round | 26/10/2021 | Zamalek | - | ENPPI | 2:0 | ||||
| 2. Round | 31/10/2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 4. Round | 19/11/2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 5. Round | 22/11/2021 | Zamalek | - | National Bank SC | 1:1 | ||||
| 6. Round | 25/11/2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 9. Round | 15/02/2022 | Smouha Sporting Club | - | Zamalek | 2:0 | ||||
| 10. Round | 02/03/2022 | Zamalek | - | Future FC | 3:2 |  |
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| 12. Round | 07/03/2022 | Zamalek | - | El Gouna | 2:1 | |
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| 11. Round | 06/04/2022 | Pyramids FC | - | Zamalek | 2:3 | ||||
| 13. Round | 09/04/2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Round | 12/04/2022 | Zamalek | - | Pharco FC | 0:0 | ||||
| 21. Round | 28/05/2022 | Zamalek | - | Ismaily | 2:1 | ||||
| 20. Round | 19/06/2022 | Al Ahly SC | - | Zamalek | 2:2 | ||||
| 31. Round | 19/08/2022 | Pharco FC | - | Zamalek | 0:1 | ||||
| 33. Round | 26/08/2022 | Al Masry Club | - | Zamalek | 0:0 |
Egypt