| 14. Round | 27/02/2021 | Club Africain | - | JS Kairouan | 4:2 | ||||
| 15. Round | 03/03/2021 | JS Kairouan | - | Olympique Béja | 0:1 | ||||
| 17. Round | 10/03/2021 | JS Kairouan | - | ES Métlaoui | 1:1 | ||||
| 21. Round | 31/03/2021 | AS Soliman | - | JS Kairouan | 2:1 |  |
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| 22. Round | 03/04/2021 | JS Kairouan | - | US Ben Guerdane | 1:3 | ||||
| 19. Round | 18/04/2021 | Espérance de Tunis | - | JS Kairouan | 3:1 |  |
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| 24. Round | 05/05/2021 | JS Kairouan | - | CA Bizertin | 1:4 | ||||
| 25. Round | 09/05/2021 | CS Sfaxien | - | JS Kairouan | 2:0 | ||||
| 26. Round | 19/05/2021 | JS Kairouan | - | US Tataouine | 0:1 |
Tunisia