1. Round | 14/08/2021 | Heracles Almelo | - | PSV Eindhoven | 0:2 | ||||
2. Round | 21/08/2021 | Sparta Rotterdam | - | Heracles Almelo | 1:1 | ||||
3. Round | 29/08/2021 | Heracles Almelo | - | NEC Nijmegen | 0:1 | ||||
5. Round | 19/09/2021 | Heracles Almelo | - | AZ Alkmaar | 3:2 | ||||
6. Round | 23/09/2021 | SC Cambuur | - | Heracles Almelo | 2:1 | ||||
7. Round | 26/09/2021 | Heracles Almelo | - | RKC Waalwijk | 1:0 | ||||
9. Round | 16/10/2021 | Go Ahead Eagles | - | Heracles Almelo | 4:2 | ||||
15. Round | 04/12/2021 | Heracles Almelo | - | sc Heerenveen | 0:1 |