| 2. Round | 29/10/2021 | US Biskra | - | JS Saoura | 2:1 |  |
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| 3. Round | 07/11/2021 | US Biskra | - | RC Rélizane | 1:0 | ||||
| 4. Round | 20/11/2021 | USM Alger | - | US Biskra | 3:0 | ||||
| 5. Round | 25/11/2021 | US Biskra | - | HB Chelghoum Laïd | 2:0 | ||||
| 7. Round | 10/12/2021 | US Biskra | - | ASO Chlef | 2:1 | ||||
| 8. Round | 17/12/2021 | MC Oran | - | US Biskra | 2:2 | ||||
| 9. Round | 24/12/2021 | US Biskra | - | CR Bélouizdad | 0:1 | ||||
| 10. Round | 29/12/2021 | NC Magra | - | US Biskra | 1:0 | ||||
| 12. Round | 07/01/2022 | MC Alger | - | US Biskra | 1:1 | ||||
| 6. Round | 11/01/2022 | JS Kabylie | - | US Biskra | 1:1 | ||||
| 13. Round | 16/01/2022 | US Biskra | - | CS Constantine | 2:0 | ||||
| 14. Round | 21/01/2022 | Paradou AC | - | US Biskra | 1:0 | ||||
| 15. Round | 25/01/2022 | US Biskra | - | Olympique Médéa | 2:1 | ||||
| 16. Round | 29/01/2022 | ES Sétif | - | US Biskra | 2:0 | ||||
| 17. Round | 05/02/2022 | US Biskra | - | NA Hussein Dey | 2:1 | ||||
| 18. Round | 25/02/2022 | US Biskra | - | RC Arbaâ | 1:0 | |
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| 30. Round | 14/05/2022 | CS Constantine | - | US Biskra | 0:0 | |
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| 31. Round | 20/05/2022 | US Biskra | - | Paradou AC | 1:0 | ||||
| 33. Round | 05/06/2022 | US Biskra | - | ES Sétif | 1:1 | ||||
| 34. Round | 10/06/2022 | NA Hussein Dey | - | US Biskra | 1:2 |
Algeria