| 1. Round | 16/10/2021 | Espérance Zarzis | - | Olympique Béja | 0:2 | ||||
| 2. Round | 23/10/2021 | CS Chebba | - | Espérance Zarzis | 0:0 |  |
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| 3. Round | 30/10/2021 | Espérance Zarzis | - | AS Rejiche | 0:0 | ||||
| 5. Round | 07/11/2021 | Espérance Zarzis | - | AS Soliman | 0:0 | ||||
| 6. Round | 18/11/2021 | Club Africain | - | Espérance Zarzis | 1:0 | |
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| 7. Round | 21/11/2021 | Espérance Zarzis | - | US Monastir | 0:1 |
Tunisia