| 2. Round | 31/10/2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 4. Round | 19/11/2021 | Tala'ea El Gaish SC | - | Ghazl Al Mehalla | 0:0 | ||||
| 6. Round | 26/11/2021 | Tala'ea El Gaish SC | - | Future FC | 1:0 |  |
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| 7. Round | 21/12/2021 | Pyramids FC | - | Tala'ea El Gaish SC | 3:0 | ||||
| 8. Round | 09/02/2022 | Tala'ea El Gaish SC | - | El Gouna | 0:1 | ||||
| 9. Round | 14/02/2022 | Misr lel-Maqasah SC | - | Tala'ea El Gaish SC | 0:0 | ||||
| 10. Round | 21/02/2022 | Tala'ea El Gaish SC | - | Pharco FC | 1:0 |  |
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| 12. Round | 09/03/2022 | Tala'ea El Gaish SC | - | Al Masry Club | 1:0 | ||||
| 13. Round | 17/03/2022 | El Sharkia Lel Dokhan | - | Tala'ea El Gaish SC | 0:0 | ||||
| 14. Round | 14/04/2022 | Tala'ea El Gaish SC | - | ENPPI | 1:1 | ||||
| 15. Round | 19/04/2022 | Tala'ea El Gaish SC | - | Ceramica Cleopatra | 1:0 | ||||
| 18. Round | 09/05/2022 | Tala'ea El Gaish SC | - | National Bank SC | 1:1 | ||||
| 20. Round | 21/05/2022 | Tala'ea El Gaish SC | - | Al Mokawloon | 1:0 |
Tunisia