| 1. Round | 26/10/2021 | Zamalek | - | ENPPI | 2:0 | ||||
| 2. Round | 31/10/2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 3. Round | 05/11/2021 | Zamalek | - | Al Ahly SC | 3:5 | ||||
| 4. Round | 19/11/2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 5. Round | 22/11/2021 | Zamalek | - | National Bank SC | 1:1 | ||||
| 6. Round | 25/11/2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 7. Round | 21/12/2021 | Al Mokawloon | - | Zamalek | 1:2 |  |
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| 8. Round | 25/12/2021 | Zamalek | - | Ghazl Al Mehalla | 4:0 | |
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| 9. Round | 15/02/2022 | Smouha Sporting Club | - | Zamalek | 2:0 | ||||
| 19. Round | 17/05/2022 | Zamalek | - | Tala'ea El Gaish SC | 0:1 | ||||
| 21. Round | 28/05/2022 | Zamalek | - | Ismaily | 2:1 | ||||
| 20. Round | 19/06/2022 | Al Ahly SC | - | Zamalek | 2:2 | ||||
| 22. Round | 22/06/2022 | National Bank SC | - | Zamalek | 1:2 | ||||
| 23. Round | 28/06/2022 | Zamalek | - | Ceramica Cleopatra | 3:2 | ||||
| 24. Round | 12/07/2022 | Zamalek | - | Al Mokawloon | 1:0 |  |
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| 25. Round | 16/07/2022 | Ghazl Al Mehalla | - | Zamalek | 0:2 |
Morocco