| 16. Round | 10/12/2000 | KRC Harelbeke | - | Sporting Lokeren | 1:6 | ||||
| 17. Round | 16/12/2000 | KSK Beveren | - | KRC Harelbeke | 2:1 | ||||
| 18. Round | 20/12/2000 | Standard Liège | - | KRC Harelbeke | 3:0 | ||||
| 19. Round | 21/01/2001 | KRC Harelbeke | - | RSC Charleroi | 1:0 | ||||
| 20. Round | 28/01/2001 | RAA La Louviére | - | KRC Harelbeke | 0:2 | ||||
| 21. Round | 04/02/2001 | KRC Harelbeke | - | Royal Antwerp FC | 2:0 | ||||
| 22. Round | 10/02/2001 | Germinal Beerschot | - | KRC Harelbeke | 2:1 | ||||
| 26. Round | 18/03/2001 | KV Mechelen | - | KRC Harelbeke | 2:0 | ||||
| 27. Round | 01/04/2001 | KRC Harelbeke | - | KRC Genk | 1:2 |  |
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| 28. Round | 07/04/2001 | K.S.C. Eendracht Aalst | - | KRC Harelbeke | 0:0 |
Algeria