| 1. Round | 23/07/2021 | PFC Beroe | - | Lokomotiv Sofia | 1:0 |  |
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| 2. Round | 01/08/2021 | Lokomotiv Sofia | - | Lokomotiv Plovdiv | 1:0 | |
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| 3. Round | 06/08/2021 | CSKA 1948 Sofia | - | Lokomotiv Sofia | 1:1 | ||||
| 5. Round | 21/08/2021 | PFC Ludogorets Razgrad | - | Lokomotiv Sofia | 5:0 | ||||
| 6. Round | 27/08/2021 | Arda Kardzhali | - | Lokomotiv Sofia | 1:1 | ||||
| 7. Round | 10/09/2021 | Lokomotiv Sofia | - | Pirin Blagoevgrad | 2:1 | |
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| 8. Round | 18/09/2021 | Cherno More Varna | - | Lokomotiv Sofia | 1:1 | ||||
| 9. Round | 27/09/2021 | Lokomotiv Sofia | - | Slavia Sofia | 1:0 | ||||
| 10. Round | 02/10/2021 | Botev Vratsa | - | Lokomotiv Sofia | 2:2 | ||||
| 11. Round | 16/10/2021 | Lokomotiv Sofia | - | Levski Sofia | 1:2 | ||||
| 12. Round | 22/10/2021 | Tsarsko Selo Sofia | - | Lokomotiv Sofia | 2:0 | ||||
| 15. Round | 21/11/2021 | Lokomotiv Plovdiv | - | Lokomotiv Sofia | 2:1 |  |
Algeria