| 1. Round | 21/11/2021 | SC East Bengal | - | Jamshedpur FC | 1:1 | ||||
| 2. Round | 27/11/2021 | SC East Bengal | - | ATK Mohun Bagan FC | 0:3 | ||||
| 3. Round | 30/11/2021 | Odisha FC | - | SC East Bengal | 6:4 | ||||
| 4. Round | 03/12/2021 | Chennaiyin FC | - | SC East Bengal | 0:0 | ||||
| 7. Round | 17/12/2021 | NorthEast United FC | - | SC East Bengal | 2:0 | ||||
| 8. Round | 23/12/2021 | Hyderabad FC | - | SC East Bengal | 1:1 | ||||
| 11. Round | 07/01/2022 | SC East Bengal | - | Mumbai City FC | 0:0 | ||||
| 12. Round | 11/01/2022 | Jamshedpur FC | - | SC East Bengal | 1:0 | ||||
| 13. Round | 19/01/2022 | FC Goa | - | SC East Bengal | 1:2 | ||||
| 14. Round | 24/01/2022 | SC East Bengal | - | Hyderabad FC | 0:4 | ||||
| 15. Round | 29/01/2022 | ATK Mohun Bagan FC | - | SC East Bengal | 3:1 | ||||
| 16. Round | 02/02/2022 | SC East Bengal | - | Chennaiyin FC | 2:2 | ||||
| 17. Round | 07/02/2022 | SC East Bengal | - | Odisha FC | 1:2 | ||||
| 21. Round | 14/02/2022 | Kerala Blasters | - | SC East Bengal | 1:0 | ||||
| 18. Round | 22/02/2022 | Mumbai City FC | - | SC East Bengal | 1:0 | ||||
| 19. Round | 28/02/2022 | SC East Bengal | - | NorthEast United FC | 1:1 |
India