| 1. Round | 13/08/2000 | Club Brugge KV | - | KAA Gent | 6:2 | ||||
| 2. Round | 19/08/2000 | KAA Gent | - | KV Mechelen | 2:1 | ||||
| 3. Round | 27/08/2000 | K.S.C. Eendracht Aalst | - | KAA Gent | 1:4 |  |
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| 4. Round | 06/09/2000 | KAA Gent | - | Sint-Truidense VV | 2:1 | ||||
| 5. Round | 09/09/2000 | KVC Westerlo | - | KAA Gent | 0:0 | ||||
| 6. Round | 16/09/2000 | KAA Gent | - | KSK Beveren | 5:0 | ||||
| 7. Round | 23/09/2000 | RSC Charleroi | - | KAA Gent | 4:3 | ||||
| 8. Round | 01/10/2000 | KAA Gent | - | Royal Antwerp FC | 4:2 | ||||
| 9. Round | 14/10/2000 | RSC Anderlecht | - | KAA Gent | 2:1 | ||||
| 10. Round | 21/10/2000 | KAA Gent | - | Lierse SK (old) | 2:3 | ||||
| 11. Round | 28/10/2000 | KRC Genk | - | KAA Gent | 1:1 | ||||
| 13. Round | 18/11/2000 | KAA Gent | - | Excelsior Mouscron | 1:0 | ||||
| 14. Round | 25/11/2000 | Sporting Lokeren | - | KAA Gent | 1:1 | ||||
| 15. Round | 02/12/2000 | KAA Gent | - | Standard Liège | 2:1 | ||||
| 16. Round | 09/12/2000 | RAA La Louviére | - | KAA Gent | 1:1 | ||||
| 17. Round | 16/12/2000 | KAA Gent | - | Germinal Beerschot | 3:1 | ||||
| 21. Round | 03/02/2001 | Sint-Truidense VV | - | KAA Gent | 0:1 | ||||
| 22. Round | 10/02/2001 | KAA Gent | - | KVC Westerlo | 3:1 |
Norway