| 2. Round | 25/08/2021 | SuperSport United | - | Golden Arrows | 3:1 | ||||
| 4. Round | 19/09/2021 | Moroka Swallows | - | SuperSport United | 0:3 | ||||
| 5. Round | 25/09/2021 | SuperSport United | - | Maritzburg United | 2:1 | ||||
| 6. Round | 02/10/2021 | Chippa United | - | SuperSport United | 0:0 | ||||
| 14. Round | 08/12/2021 | Stellenbosch FC | - | SuperSport United | 0:1 | ||||
| 15. Round | 11/12/2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 | ||||
| 16. Round | 18/12/2021 | Sekhukhune United | - | SuperSport United | 0:0 | ||||
| 17. Round | 22/12/2021 | SuperSport United | - | Cape Town City FC | 3:2 | ||||
| 18. Round | 15/02/2022 | Maritzburg United | - | SuperSport United | 2:1 | ||||
| 20. Round | 27/02/2022 | SuperSport United | - | Royal AM | 0:2 | ||||
| 22. Round | 19/03/2022 | TS Galaxy | - | SuperSport United | 1:1 | ||||
| 24. Round | 05/04/2022 | SuperSport United | - | Chippa United | 1:1 | ||||
| 27. Round | 03/05/2022 | SuperSport United | - | Stellenbosch FC | 0:0 | ||||
| 29. Round | 14/05/2022 | Baroka FC | - | SuperSport United | 3:1 |
Uganda