| 2. Round | 28/08/2020 | Olympique Lyonnais | - | Dijon FCO | 4:1 |  |
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| 3. Round | 11/09/2020 | Girondins Bordeaux | - | Olympique Lyonnais | 0:0 | |
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| 1. Round | 15/09/2020 | Montpellier HSC | - | Olympique Lyonnais | 2:1 | ||||
| 4. Round | 18/09/2020 | Olympique Lyonnais | - | Nîmes Olympique | 0:0 | ||||
| 5. Round | 27/09/2020 | FC Lorient | - | Olympique Lyonnais | 1:1 | ||||
| 6. Round | 04/10/2020 | Olympique Lyonnais | - | Olympique Marseille | 1:1 | ||||
| 7. Round | 18/10/2020 | RC Strasbourg | - | Olympique Lyonnais | 2:3 | ||||
| 8. Round | 25/10/2020 | Olympique Lyonnais | - | AS Monaco | 4:1 | ||||
| 9. Round | 01/11/2020 | Lille OSC | - | Olympique Lyonnais | 1:1 | ||||
| 10. Round | 08/11/2020 | Olympique Lyonnais | - | AS Saint-Étienne | 2:1 | ||||
| 11. Round | 22/11/2020 | Angers SCO | - | Olympique Lyonnais | 0:1 | ||||
| 12. Round | 29/11/2020 | Olympique Lyonnais | - | Stade de Reims | 3:0 |  |
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| 13. Round | 06/12/2020 | FC Metz | - | Olympique Lyonnais | 1:3 | ||||
| 14. Round | 13/12/2020 | Paris Saint-Germain | - | Olympique Lyonnais | 0:1 | ||||
| 15. Round | 16/12/2020 | Olympique Lyonnais | - | Stade Brestois 29 | 2:2 | ||||
| 16. Round | 19/12/2020 | OGC Nice | - | Olympique Lyonnais | 1:4 |
France
Mali 
