1. Round | 14/08/2021 | Everton FC | - | Southampton FC | 3:1 | ||||
2. Round | 22/08/2021 | Southampton FC | - | Manchester United | 1:1 | ||||
3. Round | 28/08/2021 | Newcastle United | - | Southampton FC | 2:2 | ||||
4. Round | 11/09/2021 | Southampton FC | - | West Ham United | 0:0 | ||||
6. Round | 26/09/2021 | Southampton FC | - | Wolverhampton Wanderers | 0:1 | ||||
7. Round | 02/10/2021 | Chelsea FC | - | Southampton FC | 3:1 | ||||
8. Round | 16/10/2021 | Southampton FC | - | Leeds United | 1:0 | ||||
17. Round | 15/12/2021 | Crystal Palace | - | Southampton FC | 2:2 | ||||
26. Round | 19/02/2022 | Southampton FC | - | Everton FC | 2:0 | ||||
27. Round | 25/02/2022 | Southampton FC | - | Norwich City | 2:0 | ||||
21. Round | 10/03/2022 | Southampton FC | - | Newcastle United | 1:2 | ||||
38. Round | 22/05/2022 | Leicester City | - | Southampton FC | 4:1 |