| 18. Round | 16/01/2010 | Skoda Xanthi | - | Ergotelis | 1:0 | ||||
| 19. Round | 24/01/2010 | Panthrakikos | - | Skoda Xanthi | 1:1 | ||||
| 21. Round | 06/02/2010 | AEK Athen | - | Skoda Xanthi | 3:1 |  |
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| 22. Round | 13/02/2010 | Skoda Xanthi | - | AE Lárissa | 0:1 | ||||
| 23. Round | 20/02/2010 | AO Kavala | - | Skoda Xanthi | 2:1 | ||||
| 24. Round | 27/02/2010 | Skoda Xanthi | - | PAOK Saloniki | 0:3 | ||||
| 25. Round | 07/03/2010 | Panionios GSS | - | Skoda Xanthi | 3:0 | ||||
| 26. Round | 14/03/2010 | Levadiakos | - | Skoda Xanthi | 2:1 | |
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| 27. Round | 21/03/2010 | Skoda Xanthi | - | Asteras Tripolis | 2:0 | |
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| 28. Round | 28/03/2010 | Olympiakos Piraeus | - | Skoda Xanthi | 0:0 | ||||
| 29. Round | 11/04/2010 | Skoda Xanthi | - | Atromitos | 2:1 | ||||
| 30. Round | 18/04/2010 | Iraklis Saloniki | - | Skoda Xanthi | 2:4 | |
Romania