| 1. Round | 27/08/2010 | Panathinaikos | - | Skoda Xanthi | 1:1 |  |
|||
| 2. Round | 12/09/2010 | Skoda Xanthi | - | Panionios GSS | 1:1 | ||||
| 3. Round | 18/09/2010 | Ergotelis | - | Skoda Xanthi | 1:0 | ||||
| 5. Round | 03/10/2010 | AEK Athen | - | Skoda Xanthi | 1:0 | ||||
| 6. Round | 16/10/2010 | Skoda Xanthi | - | Olympiakos Piraeus | 0:3 | ||||
| 7. Round | 23/10/2010 | Atromitos | - | Skoda Xanthi | 1:1 | ||||
| 8. Round | 30/10/2010 | AE Lárissa | - | Skoda Xanthi | 3:0 | ||||
| 9. Round | 06/11/2010 | Skoda Xanthi | - | Iraklis Saloniki | 2:2 | ||||
| 16. Round | 04/01/2011 | Skoda Xanthi | - | Panathinaikos | 0:2 | ||||
| 18. Round | 16/01/2011 | Skoda Xanthi | - | Ergotelis | 0:1 | ||||
| 19. Round | 22/01/2011 | PAOK Saloniki | - | Skoda Xanthi | 2:1 |
Romania