| 1. Round | 16/08/2008 | AFC Tubize | - | Excelsior Mouscron | 1:2 |  |
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| 2. Round | 23/08/2008 | Excelsior Mouscron | - | KV Mechelen | 3:1 |  |
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| 3. Round | 30/08/2008 | FCV Dender EH | - | Excelsior Mouscron | 1:2 | ||||
| 4. Round | 13/09/2008 | Excelsior Mouscron | - | KAA Gent | 4:2 | |
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| 5. Round | 20/09/2008 | KVC Westerlo | - | Excelsior Mouscron | 0:0 | ||||
| 6. Round | 28/09/2008 | Excelsior Mouscron | - | KRC Genk | 1:2 | ||||
| 7. Round | 03/10/2008 | RSC Anderlecht | - | Excelsior Mouscron | 2:1 | ||||
| 8. Round | 18/10/2008 | Excelsior Mouscron | - | KSV Roeselare | 2:0 | |
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| 9. Round | 24/10/2008 | KV Kortrijk | - | Excelsior Mouscron | 2:2 | ||||
| 10. Round | 01/11/2008 | Excelsior Mouscron | - | Cercle Brugge | 0:1 | ||||
| 11. Round | 08/11/2008 | RAEC Mons | - | Excelsior Mouscron | 0:0 | ||||
| 12. Round | 15/11/2008 | Excelsior Mouscron | - | Sporting Charleroi | 2:1 | ||||
| 13. Round | 22/11/2008 | Standard Liège | - | Excelsior Mouscron | 3:1 | |
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| 14. Round | 29/11/2008 | Excelsior Mouscron | - | Sporting Lokeren | 2:0 | ||||
| 15. Round | 06/12/2008 | Germinal Beerschot | - | Excelsior Mouscron | 3:0 | ||||
| 16. Round | 13/12/2008 | SV Zulte Waregem | - | Excelsior Mouscron | 2:1 |
Belgium