| 1. Round | 22/08/2020 | FK Oleksandriya | - | FK Mariupol | 4:1 | ||||
| 2. Round | 13/09/2020 | Zorya Lugansk | - | FK Mariupol | 0:1 | ||||
| 3. Round | 18/09/2020 | SK Dnipro-1 | - | FK Mariupol | 1:2 | ||||
| 4. Round | 26/09/2020 | Vorskla Poltava | - | FK Mariupol | 0:0 |  |
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| 10. Round | 20/11/2020 | Rukh Lviv | - | FK Mariupol | 0:0 | ||||
| 11. Round | 27/11/2020 | FK Lviv | - | FK Mariupol | 1:3 |  |
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| 12. Round | 05/12/2020 | FK Mariupol | - | Dinamo Kiev | 1:2 | |
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| 13. Round | 13/12/2020 | Desna Chernigov | - | FK Mariupol | 2:0 | ||||
| 14. Round | 14/02/2021 | FK Mariupol | - | FK Oleksandriya | 0:1 | ||||
| 15. Round | 20/02/2021 | FK Mariupol | - | Zorya Lugansk | 0:1 | ||||
| 16. Round | 27/02/2021 | FK Mariupol | - | SK Dnipro-1 | 2:2 | ||||
| 18. Round | 14/03/2021 | FK Mariupol | - | Kolos Kovalivka | 1:4 | ||||
| 21. Round | 10/04/2021 | FK Mariupol | - | Shakhtar Donetsk | 0:3 | ||||
| 25. Round | 05/05/2021 | Dinamo Kiev | - | FK Mariupol | 0:0 |
Ukraine