| 1. Round | 16/10/2021 | Espérance Zarzis | - | Olympique Béja | 0:2 | ||||
| 2. Round | 23/10/2021 | CS Chebba | - | Espérance Zarzis | 0:0 | ||||
| 3. Round | 30/10/2021 | Espérance Zarzis | - | AS Rejiche | 0:0 | ||||
| 4. Round | 04/11/2021 | Étoile du Sahel | - | Espérance Zarzis | 1:1 | ||||
| 5. Round | 07/11/2021 | Espérance Zarzis | - | AS Soliman | 0:0 | ||||
| 6. Round | 18/11/2021 | Club Africain | - | Espérance Zarzis | 1:0 |
Tunisia