| 1. Round | 17/10/2021 | US Tataouine | - | CA Bizertin | 2:1 | ||||
| 2. Round | 23/10/2021 | CA Bizertin | - | ES Hammam Sousse | 0:0 | ||||
| 3. Round | 30/10/2021 | CA Bizertin | - | Espérance de Tunis | 1:2 | ||||
| 4. Round | 03/11/2021 | CS Hammam-Lif | - | CA Bizertin | 0:1 | ||||
| 5. Round | 06/11/2021 | CA Bizertin | - | ES Métlaoui | 1:0 | ||||
| 6. Round | 17/11/2021 | CS Sfaxien | - | CA Bizertin | 1:2 |  |
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| 7. Round | 21/11/2021 | CA Bizertin | - | US Ben Guerdane | 1:2 |
Tunisia