| 1. Round | 16/10/2021 | Espérance Zarzis | - | Olympique Béja | 0:2 | ||||
| 2. Round | 23/10/2021 | CS Chebba | - | Espérance Zarzis | 0:0 | ||||
| 3. Round | 30/10/2021 | Espérance Zarzis | - | AS Rejiche | 0:0 | ||||
| 4. Round | 04/11/2021 | Étoile du Sahel | - | Espérance Zarzis | 1:1 | ||||
| 5. Round | 07/11/2021 | Espérance Zarzis | - | AS Soliman | 0:0 | ||||
| 6. Round | 18/11/2021 | Club Africain | - | Espérance Zarzis | 1:0 | ||||
| 7. Round | 21/11/2021 | Espérance Zarzis | - | US Monastir | 0:1 | ||||
| 10. Round | 09/03/2022 | AS Rejiche | - | Espérance Zarzis | 1:0 | ||||
| 12. Round | 06/04/2022 | AS Soliman | - | Espérance Zarzis | 2:1 | ||||
| 13. Round | 10/04/2022 | Espérance Zarzis | - | Club Africain | 0:1 | ||||
| 14. Round | 13/04/2022 | US Monastir | - | Espérance Zarzis | 0:1 |
Tunisia