| 5. Round | 27/08/2005 | Southampton FC | - | Crewe Alexandra | 2:0 | ||||
| 25. Round | 26/12/2005 | Watford FC | - | Southampton FC | 3:0 | ||||
| 26. Round | 28/12/2005 | Southampton FC | - | Sheffield United | 0:1 | ||||
| 28. Round | 02/01/2006 | Southampton FC | - | Brighton & Hove Albion | 2:1 | ||||
| 29. Round | 14/01/2006 | Queens Park Rangers | - | Southampton FC | 1:0 | ||||
| 17. Round | 25/01/2006 | Southampton FC | - | Crystal Palace | 0:0 | ||||
| 31. Round | 31/01/2006 | Plymouth Argyle | - | Southampton FC | 2:1 | ||||
| 32. Round | 04/02/2006 | Southampton FC | - | Derby County | 0:0 | ||||
| 33. Round | 10/02/2006 | Reading FC | - | Southampton FC | 2:0 | ||||
| 34. Round | 15/02/2006 | Southampton FC | - | Preston North End | 0:0 | ||||
| 36. Round | 25/02/2006 | Southampton FC | - | Sheffield Wednesday | 3:0 | ||||
| 37. Round | 04/03/2006 | Southampton FC | - | Coventry City | 1:1 | ||||
| 40. Round | 25/03/2006 | Sheffield United | - | Southampton FC | 3:0 | ||||
| 43. Round | 15/04/2006 | Stoke City | - | Southampton FC | 1:2 | ||||
| 44. Round | 17/04/2006 | Southampton FC | - | Millwall FC | 2:0 | ||||
| 45. Round | 22/04/2006 | Crystal Palace | - | Southampton FC | 2:1 | ||||
| 46. Round | 30/04/2006 | Southampton FC | - | Leicester City | 2:0 |  |
England
