| 2. Round | 31/01/2010 | River Plate | - | Central Español | 3:3 | ||||
| 3. Round | 06/02/2010 | Central Español | - | Cerro Largo | 1:2 |  |
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| 1. Round | 10/02/2010 | Racing | - | Central Español | 1:0 | ||||
| 4. Round | 13/02/2010 | Defensor Sporting | - | Central Español | 3:4 | ||||
| 5. Round | 20/02/2010 | Central Español | - | CA Cerro | 1:2 | ||||
| 7. Round | 06/03/2010 | Central Español | - | Tacuarembó | 4:1 | |
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| 8. Round | 14/03/2010 | Central Español | - | Peñarol | 0:2 | ||||
| 9. Round | 21/03/2010 | Central Español | - | Nacional | 0:2 | ||||
| 10. Round | 27/03/2010 | Liverpool | - | Central Español | 0:2 | ||||
| 11. Round | 04/04/2010 | Central Español | - | Atenas | 1:0 | ||||
| 12. Round | 11/04/2010 | Cerrito | - | Central Español | 1:3 | ||||
| 13. Round | 17/04/2010 | Central Español | - | Danubio | 2:0 |  |
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| 14. Round | 25/04/2010 | Rampla Juniors | - | Central Español | 0:0 | ||||
| 15. Round | 02/05/2010 | Fénix | - | Central Español | 2:2 | |
Uruguay