| 8. Round | 10/09/2021 | Spartak Subotica | - | TSC Bačka Topola | 0:0 | ||||
| 9. Round | 18/09/2021 | FK Čukarički | - | Spartak Subotica | 2:1 | ||||
| 10. Round | 22/09/2021 | Spartak Subotica | - | Proleter Novi Sad | 1:2 | ||||
| 11. Round | 26/09/2021 | Partizan | - | Spartak Subotica | 5:0 | ||||
| 12. Round | 02/10/2021 | Spartak Subotica | - | FK Voždovac | 0:4 | ||||
| 13. Round | 15/10/2021 | FK Novi Pazar | - | Spartak Subotica | 0:1 | ||||
| 14. Round | 23/10/2021 | Spartak Subotica | - | FK Metalac | 2:0 | ||||
| 17. Round | 21/11/2021 | Spartak Subotica | - | FK Radnički 1923 | 1:1 | ||||
| 18. Round | 28/11/2021 | Crvena Zvezda | - | Spartak Subotica | 3:0 | ||||
| 20. Round | 14/12/2021 | Vojvodina | - | Spartak Subotica | 2:3 | ||||
| 21. Round | 18/12/2021 | FK Napredak | - | Spartak Subotica | 1:0 | ||||
| 22. Round | 14/02/2022 | Spartak Subotica | - | Radnik Surdulica | 0:2 | ||||
| 23. Round | 19/02/2022 | TSC Bačka Topola | - | Spartak Subotica | 2:1 | ||||
| 26. Round | 06/03/2022 | Spartak Subotica | - | Partizan | 0:1 | ||||
| 28. Round | 20/03/2022 | Spartak Subotica | - | FK Novi Pazar | 1:2 | ||||
| 29. Round | 02/04/2022 | FK Metalac | - | Spartak Subotica | 2:0 |
Serbia