3. Round | 29/01/2022 | Cortuluá | - | Santa Fe | 1:1 | ||||
8. Round | 19/02/2022 | Santa Fe | - | Independiente Medellín | 1:0 | ||||
9. Round | 01/03/2022 | Patriotas FC | - | Santa Fe | 1:1 | ||||
11. Round | 17/03/2022 | Deportivo Pasto | - | Santa Fe | 2:4 | ||||
14. Round | 04/04/2022 | Santa Fe | - | Unión Magdalena | 1:0 | ||||
15. Round | 10/04/2022 | Envigado FC | - | Santa Fe | 1:0 | ||||
16. Round | 16/04/2022 | Santa Fe | - | Alianza Petrolera | 0:1 | ||||
17. Round | 25/04/2022 | Millonarios | - | Santa Fe | 2:1 | ||||
18. Round | 01/05/2022 | Santa Fe | - | Jaguares de Córdoba | 4:0 | ||||
19. Round | 07/05/2022 | Deportivo Cali | - | Santa Fe | 1:1 | ||||
20. Round | 15/05/2022 | Once Caldas | - | Santa Fe | 2:2 |