| 1. Round | 11/09/2021 | KF Tiranë | - | KF Skënderbeu | 4:2 | ||||
| 2. Round | 18/09/2021 | KF Skënderbeu | - | FK Partizani | 1:1 | ||||
| 3. Round | 27/09/2021 | Egnatia Rrogozhine | - | KF Skënderbeu | 1:1 | ||||
| 4. Round | 02/10/2021 | KF Skënderbeu | - | FK Vllaznia | 0:0 | ||||
| 5. Round | 16/10/2021 | KS Kastrioti | - | KF Skënderbeu | 2:0 | ||||
| 6. Round | 24/10/2021 | KF Skënderbeu | - | Dinamo Tiranë | 0:1 | ||||
| 7. Round | 30/10/2021 | KF Laçi | - | KF Skënderbeu | 2:0 | ||||
| 8. Round | 06/11/2021 | KF Skënderbeu | - | FK Kukësi | 2:1 |
Ghana