| 14. Round | 19/01/2022 | Birkirkara FC | - | Balzan FC | 3:2 | ||||
| 15. Round | 23/01/2022 | Floriana FC | - | Birkirkara FC | 1:0 | ||||
| 13. Round | 26/01/2022 | Hamrun Spartans | - | Birkirkara FC | 0:0 | ||||
| 16. Round | 30/01/2022 | Birkirkara FC | - | Gżira United | 1:0 | ||||
| 17. Round | 06/02/2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 19. Round | 19/02/2022 | Hibernians FC | - | Birkirkara FC | 2:3 | ||||
| 20. Round | 27/02/2022 | Birkirkara FC | - | St. Luċija FC | 2:3 |  |
Ghana